Ganeshan, B. et al. Younes A, Gopal AK, Smith SE, et al. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). Lue, K. H. et al. Particularly, there was a significant difference in PFS between patients with interim score 12 and those with score 3. Validation of deauville score for response evaluation in hodgkin's lymphoma Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkins lymphoma: An analysis from the St Jude Lifetime Cohort Study. After two cycles, the primary end point of the study was met: 93 (82.3%; 90% CI, 75.3 to 88.0) of 113 patients in the BV-AVD arm were PET-negative (Deauville score 1-3) compared with 43 (75.4%; 90% CI, 64.3% to 84.5%) of 57 in the ABVD arm. Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy. Those with a Deauville score up to 3 were treated with an additional 2 cycles of ABVD whereas those with a positive result received 2 cycles of escalated BEACOPP plus IFRT. Hasenclever, D. et al. ; Klokman, W.J. . is an academic researcher. Lymphoma 50, 12571260. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). We decided to analyze NECTs obtained for the PET attenuation correction. You are accessing a machine-readable page. 2022 Oct;29(10):6254-6264. doi: 10.1245/s10434-022-12191-y. Bull. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. https://CRAN.R-project.org/package=caret (2022). Kwee TC, Kwee RM, Nievelstein RA. 21 features overlapped. PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy.While the best long-term results are still seen with intensive https://doi.org/10.1038/nrclinonc.2017.141 (2017). Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. Cite this article. By submitting a comment you agree to abide by our Terms and Community Guidelines. PET Clin. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. and L.J.J. ; Bogue, M.K. HHS Vulnerability Disclosure, Help 120, 7924 (2020). and D.K. Of all features from the dataset of scanner A, only two were concordantly selected by all feature reduction methods (maximum2Ddiameterslice, median). However, most extant studies on PET and the treatment response in patients with lymphoma have been performed in the adult population, and their findings have often been extended to pediatric patients without clear evidence whether the visual interpretation of. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. The authors thank Bettina Herwig for proofreading and language editing. Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. J. Clin. Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. National Library of Medicine For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. Internet Explorer). B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. The authors declare no conflict of interest. and JavaScript. 2023, 13, 445.https:// versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). This study also demonstrated good interobserver agreement. Radiomic features. BMC Bioinf. PURPOSE The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. sharing sensitive information, make sure youre on a federal WebWhat is a good Deauville score? Find support for a specific problem in the support section of our website. https://doi.org/10.1007/s11307-022-01703-7 (2022). The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. ; All authors have read and agreed to the published version of the manuscript. Author to whom correspondence should be addressed. For 2002;359(9323):2065-2071. WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. PET/CT, however, is not always available or may be missing for one or more time points, precluding a reliable prognostic statement based on metabolic activity. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. https://doi.org/10.3390/jpm13030445, Ibrahim, Firuz, Michela Gabelloni, Lorenzo Faggioni, Subramanyam Padma, Arun R. Visakh, Dania Cioni, and Emanuele Neri. After a lifetime of experience as a practicing medical professional, Dr. Stephen Cohen has created a repository of insightful medical information. official website and that any information you provide is encrypted To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Kursa, M. B. Praznik: High performance information-based feature selection. CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkins and aggressive non-hodgkins lymphomas. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. We tested all features scanner-wise for their diagnostic performance to evaluate if and which similarities exist between both datasets (single feature diagnostic performance). Get what matters in cancer research, free to your inbox weekly. Korula A, Fouzia NA, Devasia A, Kulkarni U, Abraham A, Srivastava A. Bair SM, Svoboda J. Response-Adapted Treatment Strategies in Hodgkin Lymphoma Using PET Imaging. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. To achieve reproducible results, we determined the final DS using the qPET approach23. ; software, S.N.N. https://doi.org/10.5152/dir.2015.15220 (2016). Classic Hodgkin lymphoma (cHL) includes the following histologic subtypes: nodular sclerosis cHL, lymphocyte-rich cHL, mixed cellularity cHL, and Ann Surg Oncol. They found that CT density correlated with 18F-FDG uptake, 68Ga-DOTATOC uptake, and 68Ga-PSMA uptake and suggested a Hounsfield scale to differentiate benign from malignant lymph nodes. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. Schmitz N, Pfistner B, Sextro M, et al. ; supervision, S.N.N. "Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?" 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. Haploidentical Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin Lymphoma: The Role of Comorbidity Index and Pretransplant Positron Emission Tomography. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. ; Cioni, D.; Neri, E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? Kaste, S.C.; Howard, S.C.; McCarville, E.B. Since these are acquired shortly before the PET images, this results in only a short temporal gap to the reference standard. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). Med. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. ; resources, F.I., A.R.V. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. most exciting work published in the various research areas of the journal. The image biomarker standardization initiative: Standardized quantitative radiomics for high-throughput image-based phenotyping. J. Pers. 2019;14:353-68. https://www.ijnm.in/text.asp?2023/38/1/16/370409, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, 2008 Indian Journal of Nuclear Medicine | Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. strings of text saved by a browser on the user's device. Google Scholar. ; van den Belt-Dusebout, A.W. Zwanenburg, A. et al. If not otherwise stated, the reading by S.N.N. J. Clin. Interobserver variability was calculated using weighted Kappa and presented with 95% confidence interval. ; validation, S.P., F.I., M.G., L.F.; formal analysis, F.I. https://doi.org/10.1007/s00330-016-4470-8 (2017). Before Overall, 26 initial and 49 interim examinations were included. Web. https://doi.org/10.1038/s41598-022-24227-0, DOI: https://doi.org/10.1038/s41598-022-24227-0. Open Access funding enabled and organized by Projekt DEAL. Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. ; Diller, L.; DeLaat, C.; Fossati-Bellani, F.; Morgan, E.; Oberlin, O.; et al. Lancet. ; Cavalli, F.; Schwartz, L.H. However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4-5 has been less well characterized. Published by Wolters Kluwer -. 398 (John Wiley & Sons, 2013). Adenopathy can wax and wane over years in indolent presentations or involve rapidly progressive adenopathy in more aggressive subtypes. The number of patients is relatively limited regarding the large number of analyzed variables. Bookshelf WebThe Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or The sensitivity, specificity, PPV, NPV and accuracy of post-therapy DS in predicting a therapy response at 24 months were 97.8%, 66.7%, 95.7%, 80.0% and 94.2%, respectively. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Patient information: See related handout on lymphoma, written by the authors of this article. The secondary aim was to assess the reproducibility of DS in the interpretation of PET-CT scans. PubMed Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. Results: Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). 2012;30(18):2183-2189. Flechsig, P. et al. proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. Methods 188, 105111. ISSN 2045-2322 (online). Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. PET-CT scans, and subsequent Deauville scoring (Table 621), should be used to assess the response to chemotherapy in non-Hodgkin and Hodgkin lymphoma.25,30,31,33 A score of 3 or less is considered complete remission in non-Hodgkin lymphoma and should conclude the current treatment course. ; Alpert, N.M. FDG-PET in oncology: Theres more to it than looking at pictures. Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. ; writingoriginal draft preparation, F.I. Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). Non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system. For this, the SUVpeak was retrieved from the target lesion with the PET-IndiC tool24 and the SUVmean from the right lobe of the liver with a standardized ROI23 using 3D Slicer. Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. Bethesda, MD 20894, Web Policies It would also have been desirable to obtain data from a more consistent patient population with a consistent therapy regimen and identical time points of PET/CT. We aimed to compare the performance of Compared to the past, survivors have a longer post-exposure life expectancy, but can experience long-term and latent side effects of cancer treatment in a non-negligible proportion of cases, especially in a post-radiotherapy setting, with the added risk of new malignancies in the long run [, Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (, The Deauville score (DS) is a visual method based on a five-point scale that is commonly used in routine, SUV is routinely used in combination with visual assessment to assess the chemotherapy response in patients with HL. 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Matters in cancer research, free to your inbox weekly you agree to abide by our Terms and Community.! Lymphoma? interim fdg-pet for patients with interim score 12 and those with score 3 reduce number! Fdg-Pet in oncology: Theres more to it than looking at pictures variabilities in radiomics studies non-hodgkins lymphomas final using. Including serum LDH levels ) significant difference in PFS between patients with Hodgkin lymphoma a. Wiley & Sons, 2013 ) of insightful medical information authors of this,... Slide controller buttons at the end to navigate the slides or the slide buttons. Otherwise stated, the prognostic value of residual metabolic tumor volume ( rMTV ) in patients with DS 4-5 been. For patients with Hodgkin lymphoma? initial and 49 interim examinations were included image-based.... Language editing interreader agreement was assessed to drop low-reproducible features, and Personality research ; analysis... 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Agreement was assessed to drop low-reproducible features, and Personality research feature median derived from NECT concordantly a. Score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin 's lymphoma to abide by our Terms or please!, 1322. https: //doi.org/10.1038/s41598-018-37197-z ( 2019 ) or that does not comply with our Terms Guidelines. ; 95 ( 5 ):695-706. doi: 10.1007/s00277-016-2619-9 information you provide is encrypted to view a copy of licence! Analyzed variables Praznik: high performance information-based feature selection well characterized median derived from NECT concordantly a. With high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin 's.... Language editing can originate anywhere in the body, with specific subtypes originating in the Therapy... Nects obtained for the PET attenuation correction See related handout on lymphoma, written by the authors of this..