Any time youre considering taking a supplement, its important to discuss this with your doctor or pharmacist. If youve had an allergic reaction to Zetia or any of its ingredients, you should not take Zetia. Tell them about all prescription, over-the-counter, and other drugs you take. Your doctor will determine the best dosage to fit your needs. Talk with your doctor about birth control options that may be best for you. Zetia has a well-documented safety profile. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. For more information about taking Zetia during pregnancy, see the Zetia and pregnancy section above. If the side effects seem life threatening or if you think youre having a medical emergency, immediately call 911 or your local emergency number. Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. If you have multiple health conditions, your doctor may recommend other medications for you to take with Zetia. Absorption isnt affected by food. You should also look for supplements from reputable manufacturers. If your muscle-related side effects dont go away or become severe, tell your doctor right away. Avoid eating foods high in fat or cholesterol, or Zetia will not be as effective. tightness of chest or wheezing. However, side effects are generally mild and go away as the body adjusts to the medication. But, they can have side effects and might not be right for you. However, you shouldnt stop taking Zetia without first talking with your doctor. In clinical studies that lasted an average of 12 weeks, Zetia was compared with a placebo (a treatment with no active drug). Side effects could occur in children who are breastfed by someone taking a statin drug. They can give you tips on how to deal with any side effects that may be bothersome. The generic is considered to be as safe and effective as the original drug. Postural orthostatic tachycardia syndrome (POTS) or chronic orthostatic intolerance (OI) is classified as an autonomic dysfunction of the nervous system from an abnormal vasovagal response.. Recently, POTS has been diagnosed in some people who have had COVID-19. It can cause mild side effects and, less commonly, serious side effects. Currently GARD aims to provide the following information for this disease: Population Estimate: This section is currently in development. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. If you become pregnant while taking Zetia alone or with a statin drug, tell your doctor about your pregnancy right away. stomach pain. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Temporary excursions of 59F to 86F (15C to 30C) are allowed. We've provided a list of the best at-home tests for. Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. Zetias effect on cardiovascular morbidity and mortality isnt known. But over time, heavy alcohol use can damage your liver. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . Bock's fainting spells are one of the hallmarks of POTS. In the video she posted on Thursday, the "Real Housewives of New York City" alum detailed her suffering from a severe dehydration issue and shared that her doctor . The generic form of Zetia costs about the same as the generic form of Crestor. Learn about the drugs dosages, forms, strengths, and more. * This is a partial list of mild side effects from Zetia. Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. They may be able to help determine whats causing your hair loss. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. zetia. You may be able to find testimonials online from people who take Zetia. The symptoms develop immediately and include dizziness and an intense headache. Hot and cold spells. Zetia is available in a strength of 10 milligrams (mg). 1. Zetia is meant to be used in combination with a diet thats low in saturated fat and cholesterol. Statins are cholesterol drugs that may be taken with Zetia. If youre concerned about weight gain while using Zetia, talk with your doctor. High cholesterol occurs when you have more cholesterol in your blood than your body needs. But in studies, some people had to stop taking the drug due to feeling dizzy. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Zetia isnt a statin drug. You may wonder how Zetia compares with other medications that are prescribed for similar uses. Within 4 to 12 hours of oral administration, a single 10-mg dose of Zetia reaches peak plasma concentrations of 3.4 to 5.5 ng/mL. (A class of drugs is a group of medications that work in a similar way.) To learn how Zetia and the other treatments in the study affected peoples levels of HDL (good) cholesterol, triglycerides, non-HDL cholesterol, and Apo B, see the prescribing information. They may be able to suggest ways to relieve this side effect. Grapefruit can prevent the breakdown of these drugs in your body. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. . The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. Physicians who treat dysautonomia can be located on our Physician List. The expiration date helps guarantee that the medication is effective during this time. Zetia can be used to treat high cholesterol or homozygous sitosterolemia (a condition that causes high fat levels) in certain people. Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. Learn more about how grapefruit may interact with medications. Can diet help improve depression symptoms? They can tell you whether the supplement may interact with any medications youre taking. Sharing this information can help you avoid potential interactions. You may find your symptoms are worse in the morning, and they may change from day to day. Zetia is also available in a generic form called ezetimibe. They often originate at the base of the skull and spreading on the back of the head and neck. The bottom line: Zetia may cause fewer side effects than statins (though some clinicians might dispute that) but Zetia may cause muscle problems and other adverse reactions. Side effects of Lipitor and Zetia that are similar include diarrhea and joint pain. This active drug is also available as a generic medication. upper respiratory tract infection, including the common cold. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. Diarrhea is a common side effect of Zetia. Liver problems. These include: Note: For more information about the potential negative effects of Zetia, see the Zetia side effects section above. Read More. It also isnt known what percentage of adults and children experienced diarrhea in clinical studies of other conditions treated with Zetia. A medication timer may be useful, too. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. Increased liver enzymes can be a sign of liver damage. However, you may still experience muscle problems if you use Zetia alone. For mixed high cholesterol, Zetia is FDA-approved to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. See the Mild side effects and Serious side effects sections above for more information. Once diagnosed, many patients face waiting lists as long as two years to get . It isnt known how often this side effect occurred with Zetia in clinical studies. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. In addition, Zetia may be used with fenofibrate to treat mixed hyperlipidemia. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . Zetia is also available in a generic form called ezetimibe. Lipitor is available in a generic form called atorvastatin. This includes grapefruit and grapefruit juice. Also tell them about any vitamins, herbs, and supplements you use. The following lists contain some of the key side effects that may occur while taking Zetia. If youve changed your diet since starting Zetia, this may be an explanation for any weight loss you may have had. Talk with your doctor to learn more about which medications are right for you. Phase IV trials are used to detect adverse drug . Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). Some common antihistamines that can cause ED are: Diphenhydramine (Benadryl) Dimenhydrinate (Dramamine) Hydroxyzine. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. If taking your dose at bedtime doesnt help, or if dizziness becomes severe, tell your doctor. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. The autonomic nervous system is in charge of all bodily functions that we don't have to think about, such as: The sympathetic nervous system is part of the autonomic nervous system. It also helps keep the drug from harming the environment. Its primary metabolic pathway is via hepatic glucuronic conjunction. The cause of the disorder is unknown. Zetia is available in a generic form called ezetimibe. Based on animal studies, Zetia may cause harm to the fetus when taken by a pregnant woman. For primary high cholesterol, Zetia is FDA-approved for use in adults and children* to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet. Theyre a type of fat found in nuts, vegetable oils, and other plant-based foods. They can both be taken with or without food. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. Brain fog. Its also unknown how many adults and children experienced muscle weakness or muscle breakdown in these studies. Your doctor may do liver function tests before you start treatment and regularly during your Zetia treatment. (For more information on the specific conditions Zetia can treat, see the Zetia uses section.). It only comes in a strength of 10 milligrams (mg). Using Zetia for high cholesterol. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. New evidence shows that the drug makers Merck and Schering-Plough have conducted several studies of their popular cholesterol medicine Zetia that raise questions about its risks to the liver, but . This is a serious medical condition that, if left untreated, can lead to kidney damage. We avoid using tertiary references. Created for people with ongoing healthcare needs but benefits everyone. Zetia is a prescription drug used to treat certain types of high cholesterol. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). Medications in this class prevent your small intestine from absorbing cholesterol. However, 0.5% of adults and children who took Zetia with a statin drug experienced muscle pain so bothersome that they had to stop treatment. The most common side effects of Zetia include: muscle or joint pain, This can cause Zetia to be less effective. * To learn more about this side effect, see the Side effects explained section below. Drugs in this class prevent your small intestine from absorbing cholesterol. Zetia is a lipid-lowering compound used to treat high cholesterol.Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches, and sinus infection ().. Serious side effects of ezetimibe include hypersensitivity reactions (including angioedema - swelling of the skin and underlying tissues of the head and neck - that can be life-threatening), skin rash . But its not clear whether this side effect occurred in studies. Stomach pains were gone after second day. Zetia can cause the breakdown of muscle tissue, which can lead to kidney failure. What causes POTS? Cardiology 33 years experience. For treatment of mixed hyperlipidemia, Zetia is indicated to reduce total cholesterol, LDL cholesterol, non-HDL cholesterol, and ApoB. They can suggest ways to help relieve your side effects, or they may recommend a different treatment option for you. 4. For more information, see the How Zetia works section below. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about any liver problems you may have and whether its safe for you to take Zetia. Zetia and Crestor have some similar side effects and others that differ. Statins shouldnt be used during pregnancy. It can develop suddenly or maybe over time. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. If you have a history of heavy alcohol use and are taking Zetia with a statin drug, you may have a higher risk of side effects. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). If you drink alcohol and have questions about drinking it during Zetia treatment, talk with your doctor. Here we look at how Zetia and Crestor are alike and different. But its not clear whether this side effect occurred in studies of the drug. During Zetia treatment, your doctor will likely recommend blood tests. joint pain *. It isnt known how long adults and children experienced diarrhea while taking Zetia in these clinical studies. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. Therefore, you shouldnt breastfeed if youre taking Zetia with a statin drug. For more information about Zetia, including details about its uses, see this in-depth article on the drug. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. If youre interested in finding an alternative to Zetia, talk with your doctor. They can suggest ways to help relieve this side effect. trouble in swallowing. Zetia may stay in your system for several days after you stop taking it. Both Zetia and Lipitor come as tablets that are swallowed. Below are examples of these side effects. Get answers to some frequently asked questions about Zetias side effects. Total cholesterol levels were reduced by an average of: LDL (bad) cholesterol levels were reduced by an average of: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. Zetia reduces the buildup of fats, cholesterol, and other substances on the artery walls (this process is known as atherosclerosis) and if taken long term it may reduce the risk of heart disease. Or they may recommend that you stop taking the medication. The following information describes dosages that are commonly used or recommended. Cholesterol is made naturally in your liver. Over an average of 8 to 12 weeks, people took either Zetia alone, Zetia with a statin drug, a statin drug alone, or a placebo. These symptoms can be signs of an infection. For more information, see the prescribing information for Zetia and Crestor. A decrease in the transport of intestinal cholesterol to the liver reduces stores of hepatic cholesterol. Zetia and Crestor are both brand-name drugs. After first three days stopped it for two days. More research is needed to know for sure. Zetia is approved to treat certain forms of high cholesterol in adults when used with a low-cholesterol diet. Zetia can also cause allergic reactions, and it has been linked to gallstones or inflammation of the . Most of Zetias side effects should go away within a few days or weeks. A large review by the American Heart Association compared studies of CoQ10. Ezetimibe may cause side effects. Zetia and Lipitor have some similar side effects and others that vary. For some drugs, doing so may lead to unwanted side effects or overdose. Dizziness is a rare side effect of taking Zetia. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. Cholesterol is a fatty substance found in the cells of your body. Zetia should be protected from moisture and shouldnt be stored in areas where it could get damp or wet, such as bathrooms. It is not yet clear what are the causes of POTS disease. However, studies have found both Zetia and Lipitor to be effective for lowering cholesterol. High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. 5.8k views Answered >2 years ago. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. This causes less cholesterol to travel from your small intestine to your liver. Zetia can cause certain side effects, some of which are more common than others. If youre taking Zetia alone, you shouldnt need to take CoQ10. Less commonly, taking Zetia may lead to serious side effects. Postural Tachycardia Syndrome (PoTS) is an abnormality of the autonomic nervous system (ANS). If you need to take these drugs together, take Zetia at least 2 hours before or 4 hours after taking cholestyramine. Note: Some of the drugs listed here are used off-label to treat these specific conditions. POTS was also linked, to a lesser degree, to Covid vaccination with an mRNA vaccine, according to the new study. Zetia isnt known to interact with grapefruit or any other foods. Tried Zetia again to rule out diet causing stomach issues but got same result. Lipitor is also FDA-approved for the following conditions when used with a low-cholesterol diet: primary dysbetalipoproteinemia in adults (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), liver complications, such as high levels of, Both Zetia and Crestor are FDA-approved to treat the following conditions* when used with a. Crestor is also FDA-approved for the following conditions in adults when used with a low-cholesterol diet: primary dysbetalipoproteinemia (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), pain on the right side of your body, below your ribs, in adults as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin drug), in adults in combination with a fenofibrate, in combination with statins, in people with hepatic disease, in combination with statins, in people with elevated hepatic transaminases, in combination with statins, during pregnancy or in someone planning to become pregnant, in combination with statins, while breastfeeding, in people who have a known allergy to Zetia. If left untreated, it can cause your kidneys to stop working properly. It's Aimee Esther here! If youre taking Zetia, talk with your doctor or pharmacist to see whether CoQ10 could be a good supplement for you. You can use the study as a second opinion to make health care decisions. Zetia side effects. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. Allergic reaction. For more information on these side effects, see Side effect details below. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. Pots or postural tachycardia syndrome is, also known as postural orthostatic tachycardia syndrome, is a condition that affects the flow of blood in the heart and brain. Cholesterol can also be found in foods such as eggs, cheese, and meat. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. Serious side effects and their symptoms can include: * You may be more likely to experience this side effect if you take Zetia with a statin drug than if you take Zetia alone. For more information, see Liver problems in the Precautions section below. (For information on side effects, see the Zetia side effects section above.). Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. Zetia may also be used off-label for other conditions. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. Less cholesterol entering your liver allows your liver to break down the cholesterol it already has stored. 2. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. The primary symptom of OI is lightheadedness or fainting. Learn about the drugs dosage, forms, strengths. The following information is provided for clinicians and other healthcare professionals. A generic drug is an exact copy of the active drug in a brand-name medication. In most cases, these side effects should be temporary. Talk with your doctor if you have questions about managing your blood pressure or blood sugar while using Zetia. Total cholesterol is the overall amount of cholesterol found in your blood. Both drugs are typically taken once each day. For most people, CoQ10 isnt a harmful or dangerous supplement. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Statins are commonly prescribed with Zetia to treat certain types of high cholesterol. Its not known if its safe to take Zetia while breastfeeding or if the drug passes into breast milk. In studies, some people had to stop taking Zetia because of this side effect. POTS is an unusual condition in which your heart rate speeds up by 30 or more beats per minute with little or no change in blood pressure. If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints. This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. The side effects from Zetia .. muscle weakness, joint pain, upper respiratory infectikns resemble the symptoms of malabsorption of Vitamin A,D, E and K. Our bodies need cholestorol to help coat our nerves and help with brain function and it naturally increases as we get older, so why are we trying to lower it, could this be why we are . Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. The insurance company will review the prior authorization request and decide if the drug will be covered. Youll likely take it once a day. Your doctor will also prescribe a low-cholesterol diet for you to follow while taking Zetia. Tramadol will usually cause a blistering type rash with itching which you do not describe. . Taking Zetia with a statin may cause this side effect. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Zetia is FDA-approved to treat certain forms of high cholesterol in adults and children. Talk with your doctor if you experience diarrhea while taking this medication. You can take Zetia with or without food. Mild side effects of Zetia when taken with a statin (another kind of cholesterol -lowering drug) may include: infection, such as a respiratory . Other interactions can increase side effects or make them more severe. Healthline Media does not provide medical advice, diagnosis, or treatment. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. As with most drugs, some people can have an allergic reaction after taking Zetia. Some people may develop mild or serious side effects during Zetia treatment. You can use the study as a second opinion to make health care decisions. diarrhea. Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Note: Zetia isnt approved to lower these types of cholesterol: Cholesterol is measured in several ways. Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. This is because every persons body responds differently to medications. * For these purposes, Zetia and Crestor are used to treat people of different ages. They may want to select a different treatment option for you. And taking it with Zetia and a statin likely wont cause any problems. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . Zinnia elegans 'Benary's Giant Golden Yellow'. voice changes. Clinical studies have shown Zetia to be effective for treating homozygous familial hypercholesterolemia when used with atorvastatin or simvastatin. Your risk of developing serious side effects may increase if you take Zetia with other medications to treat high cholesterol, such as statin drugs. 6. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Licensed healthcare professional to relieve this side effect doesnt help, or go to the when. About drug interactions that may occur while taking this medication percentage of adults and children experienced diarrhea while Zetia. Cause certain side effects to find testimonials online from people who have had.... Cholesterol drugs that may be taken with or without Food the cholesterol it already has.... Comes in a generic form called ezetimibe or muscle breakdown in these clinical studies have found Zetia. Zetia isnt known how long adults and children experienced diarrhea in clinical studies also look for supplements from manufacturers... 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